1,1,3-Tribromoacetone

Names

[ Name ]:
1,1,3-Tribromoacetone

[Synonym ]:
1,1,3-Tribromoacetone
1,1,3-tribromopropanone
1,1,3-Tribrom-aceton
1,1,3-tribromo-propan-2-one
1,3-Tribromoacetone
2-Propanone, 1,1,3-tribromo-
1,1,3-tribromo-2-propanone
2-Propanone,1,3-tribromo

Biological Activity

[Description]:

1,1,3-Tribromoacetone is an impurity of methotrexate[1]. Methotrexate, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vivo]

Methotrexate (Amethopterin) reduces thymus and spleen indices of mice. Methotrexate markedly decreases white blood cells, thymic and splenic lymphocytes at dose ≥5 mg/kg. However, there is a significant difference between the treatment plus control group and the model group (p<0.01). The combination of grape seed proanthocyanidins and Siberian ginseng eleutherosides obviously diminishes the effects of Methotrexate exposure on indices of thymus and spleens in mice[2]. Methotrexate (MTX) (2 mg/kg; i.p.; once in a week for 5 weeks) is effective in Freund's complete adjuvant-induced arthritis. The combination of Methotrexate (1 mg/kg; i.p.; once in a week for 5 weeks) and Curcumin (30 mg/kg and 100 mg/kg, thrice a week for 5 weeks; i.p.) shows a significant anti-arthritic action and protection from hematological toxicity[3].

[References]

[1]. Balwant Singh, et al. Process for the preparation of high purity methotrexate and derivatives thereof. Patent US4374987A 87A

[2]. [2].Swierkot J, et al. Methotrexate in rheumatoid arthritis. Pharmacol Rep. 2006 Jul-Aug;58(4):473-92

[3]. Banji D, et al. Evaluation of the concomitant use of methotrexate and curcumin on Freund's complete adjuvant-induced arthritis and hematological indices in rats. Indian J Pharmacol. 2011;43(5):546-550.

Chemical & Physical Properties

[ Density]:
2.6±0.1 g/cm3

[ Boiling Point ]:
266.2±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₃Br₃O

[ Molecular Weight ]:
294.767

[ Flash Point ]:
115.1±9.7 °C

[ Exact Mass ]:
291.773376

[ PSA ]:
17.07000

[ LogP ]:
3.25

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.595

Safety Information

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Related Compounds

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