4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoic acid

Names

[ CAS No. ]:
119-24-4

[ Name ]:
4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoic acid

[Synonym ]:
Folic acid impurity D
4-{[(2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}benzoic acid
4-(((2-Amino-4-oxo-3,4-dihydropteridin-6-yl)methyl)amino)benzoic acid
Benzoic acid, 4-[[(2-amino-3,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]-
p-[(2-Amino-4-hydroxy-6-pteridylmethyl)amino]benzoic Acid
4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic Acid
4-{[(2-Amino-4-oxo-1,4-dihydro-6-pteridinyl)methyl]amino}benzoic acid
MFCD00075823
Pteroic Acid

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
659.8ºC at 760mmHg

[ Melting Point ]:
>400ºC

[ Molecular Formula ]:
C₁₄H₁₂N₆O₃

[ Molecular Weight ]:
312.284

[ Flash Point ]:
352.9ºC

[ Exact Mass ]:
312.097076

[ PSA ]:
147.14000

[ LogP ]:
-0.88

[ Vapour Pressure ]:
2.61E-18mmHg at 25°C

[ Index of Refraction ]:
1.803

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22-36/37/38-43

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Calculation of absolute ligand binding free energy to a ribosome-targeting protein as a function of solvent model.

J. Phys. Chem. B 112(42) , 13411-7, (2008)

A comparative analysis is provided of the effect of different solvent models on the calculation of a potential of mean force (PMF) for determining the absolute binding affinity of the small molecule i...

X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs.

Protein Sci. 8(9) , 1765-72, (1999)

The pokeweed antiviral protein (PAP) belongs to a family of ribosome-inactivating proteins (RIP), which depurinate ribosomal RNA through their site-specific N-glycosidase activity. We report low tempe...

Activation of excitatory amino acid receptors may mediate the folate-induced stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens.

J. Pharmacol. Exp. Ther. 239(3) , 627-33, (1986)

Folic acid (FA) and 5-formyltetrahydrofolic acid (FTHF) have been shown previously to produce a marked stimulation of locomotor activity after bilateral injection into the rat nucleus accumbens. This ...