AMP-PCP

Modify Date: 2024-01-05 01:01:19

AMP-PCP structure	Common Name	AMP-PCP
	CAS Number	3469-78-1	Molecular Weight	505.20800
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₁H₁₈N₅O₁₂P₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of AMP-PCP

AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].

Name	amppcp
Synonym	More Synonyms

Description	AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90:3.8 μM (Kd)
In Vitro	AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].
References	[1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.

Molecular Formula	C₁₁H₁₈N₅O₁₂P₃
Molecular Weight	505.20800
Exact Mass	505.01600
PSA	299.33000

β,γ-methylene ATP

beta,gamma-methylene-ATP

AMP-PCP

β,γ-methylene-ATP

β,γ-meATP

adenosine-5’-[(β,γ)-methyleno]triphosphate

AMP-PCP

Use of AMP-PCP

Names

AMP-PCP Biological Activity

Chemical & Physical Properties

Synonyms