Name | AMP-PCP disodium |
---|
Description | AMP-PCP disodium is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP disodium binding favors the formation of the active homodimer of Hsp90[1]. |
---|---|
Related Catalog | |
Target |
HSP90:3.8 μM (Kd) |
In Vitro | AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1]. |
References |
Molecular Formula | C11H16N5Na2O12P3 |
---|---|
Molecular Weight | 549.17 |
Storage condition | -20°C |
Symbol |
GHS06 |
---|---|
Signal Word | Danger |
Hazard Statements | H301-H311-H315-H319-H331-H335 |
Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T |
Risk Phrases | 23/24/25-36/37/38 |
Safety Phrases | 22-26-36-45 |
RIDADR | NONH for all modes of transport |