3469-78-1

3469-78-1 structure

Name: AMP-PCP
Chemical Name: amppcp
CAS Number: 3469-78-1
Molecular Formula: C₁₁H₁₈N₅O₁₂P₃
Molecular Weight: 505.20800
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-02-16 15:51:18
Modify Date: 2024-01-05 01:01:19
AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].

Name	amppcp
Synonyms	β,γ-methylene ATP beta,gamma-methylene-ATP AMP-PCP β,γ-methylene-ATP β,γ-meATP adenosine-5’-[(β,γ)-methyleno]triphosphate

Description	AMP-PCP is an ATP analogue and can bind to Hsp90 N-terminal domain with a Kd value of 3.8 μM. AMP-PCP binding favors the formation of the active homodimer of Hsp90[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
Target	HSP90:3.8 μM (Kd)
In Vitro	AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region. In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP[1].
References	[1]. Zhang H, et al. A dynamic view of ATP-coupled functioning cycle of Hsp90 N-terminal domain. Sci Rep. 2015 Apr 13;5:9542.