FTI-2153

Modify Date: 2025-08-25 19:44:41

FTI-2153 Structure
FTI-2153 structure
 Common Name FTI-2153
CAS Number 344900-92-1 Molecular Weight 466.59600
Density N/A Boiling Point N/A
Molecular Formula C25H30N4O3S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of FTI-2153


FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].

 Names

Name fti-2153

 FTI-2153 Biological Activity

Description FTI-2153 is a potent and highly selective inhibitor of farnesyltransferase (FTase), with an IC50 of 1.4 nM. FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. Anti-cancer activity[1].
Related Catalog
References

[1]. Sun J, et al. Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine. Cancer Res. 1999 Oct 1;59(19):4919-26.

 Chemical & Physical Properties

Molecular Formula C25H30N4O3S
Molecular Weight 466.59600
Exact Mass 466.20400
PSA 121.41000
LogP 4.48120
InChIKey KZCMMZOLCBZLNG-QHCPKHFHSA-N
SMILES COC(=O)C(CCSC)NC(=O)c1ccc(CNCc2cnc[nH]2)cc1-c1ccccc1C

 Safety Information

Hazard Codes Xi
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Chemsrc provides FTI-2153(CAS#:344900-92-1) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of FTI-2153 are included as well.>> amp version: FTI-2153

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