TfR-T12 TFA

Modify Date: 2024-01-14 18:01:30

TfR-T12 TFA Structure
TfR-T12 TFA structure
Common Name TfR-T12 TFA
CAS Number 344618-30-0 Molecular Weight 1490.73
Density N/A Boiling Point N/A
Molecular Formula C71H99N19O15S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TfR-T12 TFA


TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].

 Names

Name TfR-T12

 TfR-T12 TFA Biological Activity

Description TfR-T12 is a BBB-penetrated transferrin receptor (TfR) binding peptide, displaying a binding affinity in the nM range[1][2].
Related Catalog
In Vitro TfR-T12 binds to the TfR and is subsequently internalized into TfR-expressing cells[1]. TfR-T12 is a synthetic peptide obtained by phage display, and is able to bind a different site on TfRs compared with transferrin. TfR-T12 can be chemically conjugated with a pegylated lipid derivative, 3-(N-succinimidyloxyglutaryl)aminopropyl- polyethyleneglycol(2000)- carbamyl distearoyl phosphatidylethanolamine (NHS-PEG2000-DSPE), and used as a functional material to construct the multifunctional lipid vesicles[2].
References

[1]. Carmen Wängler, et al. In Vitro and Initial in Vivo Evaluation of (68)Ga-labeled Transferrin Receptor (TfR) Binding Peptides as Potential Carriers for Enhanced Drug Transport Into TfR Expressing Cells. Mol Imaging Biol. 2011 Apr;13(2):332-41.

[2]. Li-Min Mu, et al. Lipid Vesicles Containing Transferrin Receptor Binding Peptide TfR-T 12 and Octa-Arginine Conjugate stearyl-R 8 Efficiently Treat Brain Glioma Along With Glioma Stem Cells. Sci Rep. 2017 Jun 14;7(1):3487.

 Chemical & Physical Properties

Molecular Formula C71H99N19O15S
Molecular Weight 1490.73
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