117442-28-1

117442-28-1 structure

Name: Xenin-8 TFA
Chemical Name: Xenin 8
CAS Number: 117442-28-1
Molecular Formula: C₅₁H₇₉N₁₅O₉
Molecular Weight: 1046.27000
Catalog: Research Areas Metabolic Disease
Create Date: 2018-11-29 08:23:23
Modify Date: 2025-08-29 18:53:22
Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM)[1].

Name	Xenin 8
Synonyms	xenopsin-related peptide i xp-1 his-pro-lys-arg-pro-trp-ile-leu xenopsin-related peptide 1 h-his-pro-lys-arg-pro-trp-ile-leu-oh

Description	Xenin-8, a C-terminal octapeptide, is a biologically active fragment of Xenin. Xenin is a 25-amino acid peptide of the neurotensin/xenopsin family. Xenin-8 stimulates basal insulin secretion and potentiates the insulin response to glucose in a dose-dependent manner (EC50=0.16 nM)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	Xenin-8 augments Arginine-induced insulin release (by 40%) and potentiates the glucagon responses to both Arginine (by 60%), Carbachol (by 50%). Xenin-8 counteracts the inhibition of glucagon release induced by increasing the glucose concentration[1].
References	[1]. Ramona A Silvestre, et al. Stimulatory effect of xenin-8 on insulin and glucagon secretion in the perfused rat pancreas. Regul Pept. 2003 Aug 15;115(1):25-9.