UMK57

Modify Date: 2025-08-25 05:59:11

UMK57 Structure
UMK57 structure
Common Name UMK57
CAS Number 342595-74-8 Molecular Weight 295.40
Density 1.3±0.1 g/cm3 Boiling Point 492.5±45.0 °C at 760 mmHg
Molecular Formula C17H17N3S Melting Point N/A
MSDS N/A Flash Point 251.7±28.7 °C

 Use of UMK57


UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1].

 Names

Name 5-(4-Methylphenyl)-4-(1-pyrrolidinyl)thieno[2,3-d]pyrimidine
Synonym More Synonyms

 UMK57 Biological Activity

Description UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1].
Related Catalog
References

[1]. Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 492.5±45.0 °C at 760 mmHg
Molecular Formula C17H17N3S
Molecular Weight 295.40
Flash Point 251.7±28.7 °C
Exact Mass 295.114319
LogP 4.12
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.673

 Synonyms

5-(4-Methylphenyl)-4-(1-pyrrolidinyl)thieno[2,3-d]pyrimidine
Thieno[2,3-d]pyrimidine, 5-(4-methylphenyl)-4-(1-pyrrolidinyl)-
5-(4-Methylphenyl)-4-(pyrrolidin-1-yl)thieno[2,3-d]pyrimidine
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