UMK57

Names

[ Name ]:
UMK57

[Synonym ]:
5-(4-Methylphenyl)-4-(1-pyrrolidinyl)thieno[2,3-d]pyrimidine
Thieno[2,3-d]pyrimidine, 5-(4-methylphenyl)-4-(1-pyrrolidinyl)-
5-(4-Methylphenyl)-4-(pyrrolidin-1-yl)thieno[2,3-d]pyrimidine

Biological Activity

[Description]:

UMK57 is a small molecule compound that specifically promotes k-MT attachment error correction to inhibit chromosome missegregation, which can improve chromosome segregation fidelity by destabilizing kinetochore microtubule (k-MT) attachment during mitosis[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Bernardo Orr, et al. Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells. Cell Rep. 2016 Nov 8;17(7):1755-1763.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
492.5±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₇N₃S

[ Molecular Weight ]:
295.40

[ Flash Point ]:
251.7±28.7 °C

[ Exact Mass ]:
295.114319

[ LogP ]:
4.12

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.673

Related Compounds

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