Haloperidol Metabolite II
Haloperidol Metabolite II structure
|
Common Name | Haloperidol Metabolite II | ||
|---|---|---|---|---|
| CAS Number | 34104-67-1 | Molecular Weight | 377.88000 | |
| Density | 1.247g/cm3 | Boiling Point | 531.2ºC at 760 mmHg | |
| Molecular Formula | C21H25ClFNO2 | Melting Point | 125-127°C | |
| MSDS | USA | Flash Point | 275.1ºC | |
Use of Haloperidol Metabolite IIReduced haloperidol is an active metabolite of haloperidol formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake. |
| Name | Reduced Haloperidol |
|---|---|
| Synonym | More Synonyms |
| Density | 1.247g/cm3 |
|---|---|
| Boiling Point | 531.2ºC at 760 mmHg |
| Melting Point | 125-127°C |
| Molecular Formula | C21H25ClFNO2 |
| Molecular Weight | 377.88000 |
| Flash Point | 275.1ºC |
| Exact Mass | 377.15600 |
| PSA | 43.70000 |
| LogP | 4.21420 |
| Appearance of Characters | white |
| Index of Refraction | 1.589 |
| Storage condition | Refrigerator |
| Water Solubility | DMSO: soluble10mg/mL |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933399090 |
|
~88%
Haloperidol Met... CAS#:34104-67-1 |
| Literature: Yang, Shi-Bing; Major, Felix; Tietze, Lutz F.; Rupnik, Marjan Journal of Pharmacology and Experimental Therapeutics, 2005 , vol. 315, # 1 p. 352 - 362 |
|
~%
Haloperidol Met... CAS#:34104-67-1 |
| Literature: US3936468 A1, ; |
![4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)-4-oxobutan-1-one structure](https://www.chemsrc.com/caspic/251/34104-51-3.png)
| Precursor 2 | |
|---|---|
| DownStream 1 | |
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
|
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.
Psychopharmacology 205 , 21-33, (2009) We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan... |
|
|
Determination of haloperidol and reduced haloperidol in human serum by liquid chromatography after fluorescence labeling based on the Suzuki coupling reaction.
Anal. Bioanal. Chem 386(3) , 719-24, (2006) A simultaneous method for the determination of haloperidol (HP) and its metabolite, reduced haloperidol (RHP), in human serum was developed by means of high-performance liquid chromatography (HPLC) wi... |
|
|
Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol.
Eur. Neuropsychopharmacol. 4(2) , 119-26, (1994) Plasma haloperidol (HL) and reduced haloperidol (RH) levels were measured in 60 schizophrenic patients treated with high to very high HL doses of 40-200 mg/day. Plasma samples were obtained at steady-... |
| Haloperidol metabolite II |