还原氟哌啶醇

更新时间:2024-01-03 19:55:27

还原氟哌啶醇结构式
还原氟哌啶醇结构式
品牌特惠专场
常用名 还原氟哌啶醇 英文名 Haloperidol Metabolite II
CAS号 34104-67-1 分子量 377.88000
密度 1.247g/cm3 沸点 531.2ºC at 760 mmHg
分子式 C21H25ClFNO2 熔点 125-127°C
MSDS 美版 闪点 275.1ºC

 还原氟哌啶醇用途


Reduced haloperidol is an active metabolite of haloperidol formed via reduction of haloperidol by ketone reductase. Reduced haloperidol inhibits radioligand binding to sigma-1 and dopamine D2 receptors and stimulates brain-derived neurotrophic factor (BDNF) secretion from CCF-SSTG1 and U87MG astrocytic glial cells. It also inhibits norepinephrine, dopamine, and serotonin (5-HT) reuptake.

 还原氟哌啶醇名称

中文名 还原氟哌啶醇
英文名 Reduced Haloperidol
英文别名 更多

 还原氟哌啶醇物理化学性质

密度 1.247g/cm3
沸点 531.2ºC at 760 mmHg
熔点 125-127°C
分子式 C21H25ClFNO2
分子量 377.88000
闪点 275.1ºC
精确质量 377.15600
PSA 43.70000
LogP 4.21420
外观性状 white
折射率 1.589
储存条件 Refrigerator
水溶解性 DMSO: soluble10mg/mL

 还原氟哌啶醇安全信息

个人防护装备 Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码 NONH for all modes of transport
WGK德国 3
海关编码 2933399090

 还原氟哌啶醇上下游产品

还原氟哌啶醇上游产品  2

还原氟哌啶醇下游产品  1

 还原氟哌啶醇海关

海关编码 2933399090
中文概述 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素 品名, 成分含量, 用途, 乌洛托品请注明外观, 6-己内酰胺请注明外观, 签约日期
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 还原氟哌啶醇文献26

更多文献
Antagonism by haloperidol and its metabolites of mechanical hypersensitivity induced by intraplantar capsaicin in mice: role of sigma-1 receptors.

Psychopharmacology 205 , 21-33, (2009)

We evaluated the effects of haloperidol and its metabolites on capsaicin-induced mechanical hypersensitivity (allodynia) and on nociceptive pain induced by punctate mechanical stimuli in mice.Subcutan...

Determination of haloperidol and reduced haloperidol in human serum by liquid chromatography after fluorescence labeling based on the Suzuki coupling reaction.

Anal. Bioanal. Chem 386(3) , 719-24, (2006)

A simultaneous method for the determination of haloperidol (HP) and its metabolite, reduced haloperidol (RHP), in human serum was developed by means of high-performance liquid chromatography (HPLC) wi...

Plasma reduced haloperidol/haloperidol ratios in schizophrenic patients treated with high dosages of haloperidol.

Eur. Neuropsychopharmacol. 4(2) , 119-26, (1994)

Plasma haloperidol (HL) and reduced haloperidol (RH) levels were measured in 60 schizophrenic patients treated with high to very high HL doses of 40-200 mg/day. Plasma samples were obtained at steady-...

 还原氟哌啶醇英文别名

Haloperidol metabolite II