1511-16-6

1511-16-6 structure
1511-16-6 structure
  • Name: Haloperidol (hydrochloride)
  • Chemical Name: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one,hydrochloride
  • CAS Number: 1511-16-6
  • Molecular Formula: C21H24Cl2FNO2
  • Molecular Weight: 412.32500
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2017-02-14 04:52:10
  • Modify Date: 2024-01-05 19:34:25
  • Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.

Name 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one,hydrochloride
Synonyms 4-[4-(4-chlorophenyl)-4-hydroxypiperidino]-4'-fluorobutyrophenone hydrochloride
4-[4-(4-Chlor-phenyl)-4-hydroxy-piperidino]-1-(4-fluor-phenyl)-butan-1-on,Hydrochlorid
Haloperidol chlorohydrate
Haloperidol hydrochloride [MI]
UNII-UM06W2ADRY
4-[4-(4-chloro-phenyl)-4-hydroxy-piperidino]-1-(4-fluoro-phenyl)-butan-1-one,hydrochloride
Haloperidol hydrochloride
Haloperidol chloride
Haloperidol (hydrochloride)
Description Haloperidol hydrochloride is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
Related Catalog
In Vivo Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs[1]. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 µc) of mescaline. Haloperidol has no effect on mescaline disappearance[2].
Animal Admin Male albino mice of Swiss-Webster strain (33-36 g) are used, and all substances are given by i.p. injection in a volume of 0.5 mL. CPZ, haloperidoi and mescaline are all in time form of timeir imydrochlorides and the dose solutions are prepared at concentrations of 1.0, 0.66 and 3.3 mg/mL of 0.9% saline, respectively. The doses are: CPZ, 15 mg/kg; haloperidol, 10 mg/kg; mescaline, 50 mg/kg. Mice are pretreated with either CPZ or haloperidol 30 minutes before administration of mescaline. In some instances CPZ is injected 45 minutes after mescaline. Time animals are hmoused individually in a plexiglas cage and the gross behavior and locomotor activity. At selected intervals after mescaline, groups of mice are sacrificed by decapitation. Plasma is separated and stored at -20°C. The brain, liver, kidney, lung, spleen and heart are frozen on dry ice and stored at -20°C for 18 to 20 hours before they are used for assays.
References

[1]. Joy CB, et al. Haloperidol versus placebo for schizophrenia. Cochrane Database Syst Rev. 2006 Oct 18;(4):CD003082.

[2]. Giannini AJ, et al. Acute ketamine intoxication treated by haloperidol: a preliminary study. Am J Ther. 2000 Nov;7(6):389-91.

Molecular Formula C21H24Cl2FNO2
Molecular Weight 412.32500
Exact Mass 411.11700
PSA 40.54000
LogP 5.16550
Storage condition 2-8℃