β3-AR agonist 2

Modify Date: 2025-08-27 11:11:38

β3-AR agonist 2 structure	Common Name	β3-AR agonist 2
	CAS Number	340757-05-3	Molecular Weight	562.68
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₃₈N₄O₇S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of β3-AR agonist 2

β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM.

Name	β3-AR agonist 2

Description	β3-AR agonist 2 is a potent and selective β3-adrenergic receptor (β3-AR) agonist with an EC50 of 8 nM.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Metabolic Disease
Target	EC50: 8 nM (β3-adrenergic receptor)[1]
In Vitro	β3-AR agonist 2 (Compound 26e) is found to be potent and selective at the β3 receptor, nearly completely abolishes intrinsic activity at either the β1 or β2 receptor[1].
In Vivo	β3-AR agonist 2 (Compound 26e) has significant thermogenesis effects on human β3-adrenergic receptor transgenic mice. β3-AR agonist 2 acts as a potential drug for the treatment of human obesity and type II diabetes[1].
References	[1]. Hu B, et al. (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists. J Med Chem. 2001 Apr 26;44(9):1456-66.

Molecular Formula	C₂₇H₃₈N₄O₇S
Molecular Weight	562.68

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