2213365-56-9
2213365-56-9 structure
- Name: PPARα/γ agonist 2
- Chemical Name: PPARα/γ agonist 2
- CAS Number: 2213365-56-9
- Molecular Formula: C25H20O3
- Molecular Weight: 368.42
- Catalog: Signaling Pathways Cell Cycle/DNA Damage PPAR
- Create Date: 2023-04-22 12:47:59
- Modify Date: 2024-03-06 16:02:53
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PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent[1].
| Name | PPARα/γ agonist 2 |
|---|
| Description | PPARα/γ agonist 2 is an orally active PPARα full agonist and PPARγ partial agonist. PPARα/γ agonist 2 activates PPARα and PPARγ with EC50 values of 0.95 μM and 0.91 μM respectively. PPARα/γ agonist 2 is also a PTP1B inhibitor. PPARα/γ agonist 2 is an anti-diabetic agent[1]. |
|---|---|
| Related Catalog | |
| Target |
PPARα:0.95 μM (EC50) PPARγ:0.91 μM (EC50) |
| In Vitro | PPARα/γ agonist 2 (化合物 10) 有效抑制 PTP1B，IC50 为 13.2 μM (动力学测定)[1]。 PPARα/γ agonist 2 (25 μM，30 分钟) 在 C2C12 细胞中以胰岛素-非依赖性机制增强葡萄糖的摄取，并且比 UK5099 (HY-15475) 更有效[1]。 PPARα/γ agonist 2 (25 μM，30 分钟) 降低 C2C12 细胞中的线粒体膜电位[1]。 |
| In Vivo | PPARα/γ agonist 2 (化合物 10) (25 and 50 mg/kg, p.o.) 降低 STZ 诱导的糖尿病小鼠的血糖水平和脂质含量[1]。 Animal Model: STZ-induced diabetic mice[1] Dosage: 25 and 50 mg/kg Administration: p.o. Result: Reduced the levels of TC, HDL, LDL-C, VLDL-C, and TG. Brought diabetes-induced hyperlipidemia back to normal. |
| References |
| Molecular Formula | C25H20O3 |
|---|---|
| Molecular Weight | 368.42 |