RORγt Inverse agonist 2

Modify Date: 2025-08-25 16:25:45

RORγt Inverse agonist 2 structure	Common Name	RORγt Inverse agonist 2
	CAS Number	1801197-92-1	Molecular Weight	627.54
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₇H₂₅F₈NO₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RORγt Inverse agonist 2

RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM[1].

Name	RORγt Inverse agonist 2

Description	RORγt Inverse agonist 2 is a selective, orally active RORγt inverse agonist with an EC50 of 119 nM[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> ROR Research Areas >> Inflammation/Immunology
Target	EC50: 119 nM (RORγt)[1]
In Vitro	RORγt Inverse agonist 2 (Compound 26) is inactive against RORα and RORβ in either inverse agonist or agonist mode (>40 μM)[1].
References	[1]. Duan JJ, et al. Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active RORγt Inverse Agonists. ACS Med Chem Lett. 2019 Feb 26;10(3):367-373.

Molecular Formula	C₂₇H₂₅F₈NO₅S
Molecular Weight	627.54
InChIKey	AVHWMAVUUHFRKE-DFSZNTFHSA-N
SMILES	O=C(O)C1CCC(C(=O)N2CCC(c3ccc(C(F)(C(F)(F)F)C(F)(F)F)cc3)(S(=O)(=O)c3ccc(F)cc3)C2)CC1

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Product Name: RORγt Inverse agonist 2
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