RORγt inverse agonist 22
Modify Date: 2024-04-05 19:32:29
RORγt inverse agonist 22 structure
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Common Name | RORγt inverse agonist 22 | ||
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| CAS Number | 1644029-01-5 | Molecular Weight | 489.551 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H25F2N3O5Si | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RORγt inverse agonist 22RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration. |
| Name | RORγt inverse agonist 22 |
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| Description | RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration. |
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| References | References 1. Shirai J, et al. Bioorg Med Chem. 2018 Jan 15;26(2):483-500. View Related Products by Target ROR |
| Molecular Formula | C23H25F2N3O5Si |
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| Molecular Weight | 489.551 |