Nalidixic acid sodium salt

Modify Date: 2024-01-02 17:15:59

Nalidixic acid sodium salt structure	Common Name	Nalidixic acid sodium salt
	CAS Number	3374-05-8	Molecular Weight	254.21700
	Density	1.331g/cm3	Boiling Point	413.1ºC at 760mmHg
	Molecular Formula	C₁₂H₁₁N₂NaO₃	Melting Point	229-230ºC
	MSDS	Chinese USA	Flash Point	203.6ºC
	Symbol	GHS07, GHS08	Signal Word	Danger

Use of Nalidixic acid sodium salt

Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2].

Name	Nalidixic acid sodium salt
Synonym	More Synonyms

Description	Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria[1][2].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
Target	Topoisomerase
In Vitro	Nalidixic acid is against a variety of microorganisms, it is against with Escherichia coli, Pasteurella spp., Klebsiella pneuiiioniae, Aerobacter aeroyenes, Proteus spp., Salmonella spp., Shigella spp. and Brucella spp. with MIC values of 5.0-12.5 μg/ml, 0.5-2.5 μg/ml, 0.8-25.0 μg/ml, 1.0-25.0 μg/ml, 1.25-30.0 μg/ml, 8-3.2 μg/ml, and 7.5-10.0 μg/ml, respectively[1].
In Vivo	The in vivo activity of Nalidixic acid is most pronounced against Gram-negative bacteria, while Gram-positive organisms are generally more resistant. Maximal activity is observed against systemic infections caused by E. coli, A. aerobacter, Proteus mirabilis, Shigella fkxneri, the ED50 values are 25 mg/kg, 60 mg/kg, 50 mg/kg, and 62 mg/kg, respectively[1]. The acute toxicity (LD50) of Nalidixic acid in mice following oral and parenteral administration is: oral, 3300 mg/kg; intravenous, 176 mg/kg; and subcutaneous, 500 mg/kg[1].
References	[1]. G Y LESHER,et al. 1,8-NAPHTHYRIDINE DERIVATIVES. A NEW CLASS OF CHEMOTHERAPEUTIC AGENTS. J Med Pharm Chem. 1962 Sep;91:1063-5. [2]. Anna Fàbrega, et al. Mechanism of Action of and Resistance to Quinolones. Microb Biotechnol

Density	1.331g/cm3
Boiling Point	413.1ºC at 760mmHg
Melting Point	229-230ºC
Molecular Formula	C₁₂H₁₁N₂NaO₃
Molecular Weight	254.21700
Flash Point	203.6ºC
Exact Mass	254.06700
PSA	75.02000
LogP	0.08830
Storage condition	2-8°C
Water Solubility	H2O: 50 mg/mL, clear, faintly yellow

Nalidixic acid sodium salt MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN2885500

CHEMICAL NAME :: 1,8-Naphthyridine-3-carboxylic acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-, sodium salt

CAS REGISTRY NUMBER :: 3374-05-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H12-N2-O3.Na

MOLECULAR WEIGHT :: 255.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Unscheduled DNA synthesis

TEST SYSTEM :: Rodent - rat Cells - not otherwise specified

DOSE/DURATION :: 900 mg/L

REFERENCE :: ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 60,287,1987

Symbol	GHS07, GHS08
Signal Word	Danger
Hazard Statements	H302-H317-H334
Precautionary Statements	P261-P280-P342 + P311
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Faceshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R42/43
Safety Phrases	S22-S36/37-S45
RIDADR	NONH for all modes of transport
WGK Germany	-
RTECS	QN2885500
HS Code	2933990090

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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nalidixic acid sodium

sodiumnalidixate

EINECS 222-159-7

MFCD00064376

sodium nalidixicate

sodiumnilixalate

nalidixic acid sodium salt

nalidixic acid,sodium salt

nalidixatesodium

sodium 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate

NALIDIXIC ACID SODIUM SALT MOLECULAR BIOLOGY REAGENT

8-naphthyridine-3-carboxylicacid,1-ethyl-1,4-dihydro-7-methyl-4-oxo-sodiu

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Nalidixic acid sodium salt
Price: ￥168.0/1g ￥498.0/5g ￥5378.0/100g ￥1748.0/25g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Nalidixic acid sodium salt
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Nalidixic acid sodium salt
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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