Indirubin-3'-monoxime-5-sulphonic acid

Modify Date: 2024-01-28 10:11:29

Indirubin-3'-monoxime-5-sulphonic acid structure	Common Name	Indirubin-3'-monoxime-5-sulphonic acid
	CAS Number	331467-05-1	Molecular Weight	357.34
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₁N₃O₅S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Indirubin-3'-monoxime-5-sulphonic acid

Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].

Name	3-[3-(hydroxyamino)-1H-indol-2-yl]-2-oxoindole-5-sulfonic acid
Synonym	More Synonyms

Description	Indirubin-3'-monoxime-5-sulphonic acid is a potent and selective inhibitor of CDK1, CDK5, and GSK-3β with IC50s of 5 nM, 7 nM, and 80 nM, respectively[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> GSK-3 Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Signaling Pathways >> PI3K/Akt/mTOR >> GSK-3
Target	CDK1:5 nM (IC50) CDK5:7 nM (IC50) GSK-3β:80 nM (IC50)
References	[1]. Leclerc S, et al. Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors. J Biol Chem. 2001 Jan 5;276(1):251-60.

Molecular Formula	C₁₆H₁₁N₃O₅S
Molecular Weight	357.34
Exact Mass	357.04200
PSA	140.23000
LogP	1.16390

3-[3-(Hydroxyimino)-1,3-dihydro-2H-indol-2-ylidene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid

indirubin-3'-monoxime-5-sulphonic acid

A05-A11B1-II

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: INDIRUBIN-3'-MONOXIME-5-SULPHONIC ACID
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Use of Indirubin-3'-monoxime-5-sulphonic acid

Names

Indirubin-3'-monoxime-5-sulphonic acid Biological Activity

Chemical & Physical Properties

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