PCI 29732

Modify Date: 2024-01-08 21:21:43

PCI 29732 structure	Common Name	PCI 29732
	CAS Number	330786-25-9	Molecular Weight	371.43500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₁N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PCI 29732

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1].In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2].

Name	pci-29732
Synonym	More Synonyms

Description	PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1].In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk Research Areas >> Inflammation/Immunology
References	[1]. Pan Z, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007 Jan;2(1):58-61. [2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

Description

Related Catalog

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Btk

Research Areas >> Inflammation/Immunology

References

[1]. Pan Z, et al. Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase. ChemMedChem. 2007 Jan;2(1):58-61.

[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.

Molecular Formula	C₂₂H₂₁N₅O
Molecular Weight	371.43500
Exact Mass	371.17500
PSA	78.85000
LogP	5.56410
Storage condition	2-8℃

pci 29732

DC Chemicals Limited
China
Product Name: PCI-29732
Price: $550.0/100mg $950.0/250mg $1800.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: PCI 29732
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Price: $158/10mM*1mLinDMSO

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PCI 29732

Use of PCI 29732

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PCI 29732 Biological Activity

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