PCI 29732
Modify Date: 2025-08-27 11:04:21
PCI 29732 structure
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Common Name | PCI 29732 | ||
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| CAS Number | 330786-25-9 | Molecular Weight | 371.43500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H21N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PCI 29732PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1].In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2]. |
| Name | pci-29732 |
|---|---|
| Synonym | More Synonyms |
| Description | PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1].In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2]. |
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| Related Catalog | |
| References |
| Molecular Formula | C22H21N5O |
|---|---|
| Molecular Weight | 371.43500 |
| Exact Mass | 371.17500 |
| PSA | 78.85000 |
| LogP | 5.56410 |
| InChIKey | GMJUPMONHWAZCP-UHFFFAOYSA-N |
| SMILES | Nc1ncnc2c1c(-c1ccc(Oc3ccccc3)cc1)nn2C1CCCC1 |
| Storage condition | 2-8℃ |
| pci 29732 |