PCI 29732
Names
Biological Activity
[Description]:
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.IC50 value: 8.2 nM [1]Target: Btk kinasePCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the “gatekeeper” residue [1].In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition [2].
[Related Catalog]:
[References]
[Related Small Molecules]
Acalabrutinib
|
GDC-0853
|
Evobrutinib
|
AVL-292
|
(±)-Zanubrutinib
|
ONO-4059
|
BMX-IN-1
|
GDC-0834
|
SNS-062
|
RN486
|
LFM-A13
|
Vecabrutinib
|
CGI-1746
|
BMS-986195
|
CNX-774
Chemical & Physical Properties
[ Molecular Formula ]:
C22H21N5O
[ Molecular Weight ]:
371.43500
[ Exact Mass ]:
371.17500
[ PSA ]:
78.85000
[ LogP ]:
5.56410
[ Storage condition ]:
2-8℃