Evans Blue

Modify Date: 2025-08-25 10:09:43

Evans Blue Structure
Evans Blue structure
 Common Name Evans Blue
CAS Number 314-13-6 Molecular Weight 960.805
Density N/A Boiling Point N/A
Molecular Formula C34H24N6Na4O14S4 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08		 Signal Word Danger

 Use of Evans Blue


Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively). IC50 value: 220/150 nMTarget: L-glutamate uptake receptorEvans blue is a biological dye, for detection of cell survival. Evans Blue can not penetrate healthy cell membrane, but can penetrate into death cell. Binds with high affinity to serum albumin.

 Names

Name Evans blue
Synonym More Synonyms

 Evans Blue Biological Activity

Description Evans Blue is a potent inhibitor of L-glutamate uptake via the membrane bound excitatory amino acid transporter (EAAT). Able to antagonize AMPA and kainate receptor mediated currents (IC50 values are 220 and 150 nM, respectively). IC50 value: 220/150 nMTarget: L-glutamate uptake receptorEvans blue is a biological dye, for detection of cell survival. Evans Blue can not penetrate healthy cell membrane, but can penetrate into death cell. Binds with high affinity to serum albumin.
Related Catalog

 Chemical & Physical Properties

Molecular Formula C34H24N6Na4O14S4
Molecular Weight 960.805
Exact Mass 959.982422
PSA 404.26000
LogP 10.78520
Stability Stable. Incompatible with strong reducing agents, strong oxidizing agents.
Water Solubility 280 G/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ6440000
CHEMICAL NAME :
1,3-Naphthalenedisulfonic acid, 6,6'-((3,3'-dimethyl-4,4'-biphenylylene)bis(azo))bis (4-amino-5-hydroxy-, tetrasodium salt
CAS REGISTRY NUMBER :
314-13-6
LAST UPDATED :
199710
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C34-H24-N6-O14-S4.4Na
MOLECULAR WEIGHT :
960.84
WISWESSER LINE NOTATION :
L66J BZ CSWO ESWO JQ INUNR B1 DR C1 DNUN- IL66J BZ CSWO ESWO JQ &-NA- 4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mL/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
340 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
3 mL/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
1 mL/kg
TOXIC EFFECTS :
Gastrointestinal - hypermotility, diarrhea Liver - other changes Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1 mL/kg
TOXIC EFFECTS :
Cardiac - other changes Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
620 mg/kg/10D-I
TOXIC EFFECTS :
Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
850 mg/kg/34W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Blood - leukemia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
70 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
70 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
140 mg/kg
SEX/DURATION :
female 8 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - other effects to embryo
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
150 mg/kg
SEX/DURATION :
female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - Central Nervous System
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
DNA adduct

MUTATION DATA

TYPE OF TEST :
Unscheduled DNA synthesis
TEST SYSTEM :
Rodent - hamster Liver
DOSE/DURATION :
10 umol/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 136,255,1984 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,151,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 8,151,1975 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 TOXICOLOGY REVIEW ADTEAS Advances in Teratology. (New York, NY) V.1-5, 1966-72. Discontinued. Volume(issue)/page/year: 1,131,1966 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T0844 No. of Facilities: 162 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 5350 (estimated) No. of Female Employees: 2829 (estimated)

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H350
Precautionary Statements P201-P308 + P313
Hazard Codes F:Flammable
Risk Phrases R11;R45;R63
Safety Phrases 53-45-36/37-16-36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS QJ6440000

 Articles59

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 Synonyms

Tetrasodium 6,6'-[(3,3'-dimethyl-4,4'-biphenyldiyl)di(E)-2,1-diazenediyl]bis(4-amino-5-oxido-3-sulfo-1-naphthalenesulfonate)
1,3-Naphthalenedisulfonic acid, 6,6'-[(3,3'-dimethyl[1,1'-biphenyl]-4,4'-diyl)di(E)-2,1-diazenediyl]bis[4-amino-5-hydroxy-, sodium salt (1:4)
evablin
EINECS 206-242-5
evans blue tetrasodium salt
6,6'-[(3,3'-Dimethyl[1,1'-biphenyl]-4,4'-diyl)bis(azo)]bis[4-amino-5-hydroxy-1,3-naphthalenedisulfonic Acid] Tetrasodium Salt
C.I. Direct Blue 53
Diazol Pure Blue BF
azovanblue
MFCD00004021
AZOVAN BLUE
GEIGY BLUE
t1824
4,4'-Bis[7-(1-amino-8-hydroxy-2,4-disulfo)naphthylazo]-3,3'-bitolyl Tetrasodium Salt
diazobleu
CI Direct Blue 53
blue Evan
Evans Blue
EVAN'S BLUE
Tetrasodium 6,6'-[(3,3'-dimethyl-4,4'-biphenyldiyl)di(E)-2,1-diazenediyl]bis(4-amino-5-hydroxy-1,3-naphthalenedisulfonate)
C.I. direct blue 53 tetrasodium salt
AZOVAN SODIUM
DiazoBlue
Direct Blue 53
Tetrasodium 6,6'-[(3,3'-dimethylbiphenyl-4,4'-diyl)di(E)diazene-2,1-diyl]bis(4-amino-5-hydroxynaphthalene-1,3-disulfonate)
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Related Compounds: More...
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12234-67-2
disperse blue 26
3860-63-7
Acid blue 76
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3-(Azetidin-3-yl)-1-benzylpyrrolidine
1315365-28-6
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218921-12-1
2-Oxa-7-azabicyclo[3.3.1]nonane
1334149-28-8
5-Fluoro-1h-isoindol-3-amine
1355004-72-6
2-Chlorophenyl chloranesulfonate
16475-31-3
tert-butyl N-[4-(naphthalene-1-carbonylamino)phenyl]carbamate
1098067-83-4
(1R)-1-(1,3-thiazol-5-yl)ethan-1-ol
1315378-57-4
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1513223-23-8
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128739-14-0
Chemsrc provides Evans Blue(CAS#:314-13-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Evans Blue are included as well.>> amp version: Evans Blue

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