Hyp9
Modify Date: 2024-01-09 22:52:45
Hyp9 structure
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Common Name | Hyp9 | ||
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| CAS Number | 3118-34-1 | Molecular Weight | 322.39600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H26O5 | Melting Point | 97 - 98 °C | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Hyp9Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1]. |
| Name | 1-(3-hexanoyl-2,4,6-trihydroxyphenyl)hexan-1-one |
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| Synonym | More Synonyms |
| Description | Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1]. |
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| Related Catalog | |
| In Vitro | HYP9 (0, 1, 5, 10, 15, 20, 25, 30 µM; 72 h) 以剂量依赖性方式抑制星形胶质细胞增殖[1]。 HYP9 显著抑制 AP4 过表达[1]。 Cell Proliferation Assay[1] Cell Line: CTX-TNA2 rat astrocytes Concentration: 0, 1, 5, 10, 15, 20, 25, 30 µM Incubation Time: 72 h Result: Significantly inhibit astrocyte proliferation at 5-30 µM. |
| In Vivo | HP9（鞘内注射；5 μg；1、3、5 和 7 天）通过抑制 SCl 大鼠体内模型中的 AQP4 来抑制星形胶质细胞的活化和增殖，并在 SCI 后保持神经元存活和功能恢复[1]。 Animal Model: Sprague-Dawley Rats (180-220 g; adult female)[1] Dosage: 5 μg Administration: Intrathecally; 1, 3, 5, and 7 days Result: Inhibited activation and proliferation of astrocytes in a rat SCI model. Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway. Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats. |
| References |
| Melting Point | 97 - 98 °C |
|---|---|
| Molecular Formula | C18H26O5 |
| Molecular Weight | 322.39600 |
| Exact Mass | 322.17800 |
| PSA | 94.83000 |
| LogP | 4.32940 |
| Storage condition | 2-8°C |
| RIDADR | NONH for all modes of transport |
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| HS Code | 2914400090 |
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Hyp9 CAS#:3118-34-1 |
| Literature: Chiba; Takakuwa; Tada; Yoshii Bioscience, biotechnology, and biochemistry, 1992 , vol. 56, # 11 p. 1769 - 1772 |
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Hyp9 CAS#:3118-34-1 |
| Literature: Bolte, Matthew L.; Crow, Wilfrid D.; Takahashi, Nobutaka; Sakurai, Akira; Uji-Ie, Masami; Yoshida, Shigeo Agricultural and Biological Chemistry, 1985 , vol. 49, # 3 p. 761 - 768 |
| Precursor 3 | |
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| DownStream 0 | |
| HS Code | 2914400090 |
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| Summary | 2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response.
J. Exp. Med. 212 , 1883-99, (2015) Leukocyte transendothelial migration (TEM) is a tightly regulated, multistep process that is critical to the inflammatory response. A transient increase in endothelial cytosolic free calcium ion conce... |
| Hyp9 |