Hyp9

Names

[ Name ]:
Hyp9

[Synonym ]:
Hyp9

Biological Activity

[Description]:

Hyp9 is a transient receptor potential canonical 6 (TRPC6)-specific agonist. Hyp9 can be used for the research of spinal cord injury (SCI)[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel

Research Areas >> Neurological Disease

[In Vitro]

HYP9 (0, 1, 5, 10, 15, 20, 25, 30 µM; 72 h) 以剂量依赖性方式抑制星形胶质细胞增殖[1]。 HYP9 显著抑制 AP4 过表达[1]。 Cell Proliferation Assay[1] Cell Line: CTX-TNA2 rat astrocytes Concentration: 0, 1, 5, 10, 15, 20, 25, 30 µM Incubation Time: 72 h Result: Significantly inhibit astrocyte proliferation at 5-30 µM.

[In Vivo]

HP9（鞘内注射；5 μg；1、3、5 和 7 天）通过抑制 SCl 大鼠体内模型中的 AQP4 来抑制星形胶质细胞的活化和增殖，并在 SCI 后保持神经元存活和功能恢复[1]。 Animal Model: Sprague-Dawley Rats (180-220 g; adult female)[1] Dosage: 5 μg Administration: Intrathecally; 1, 3, 5, and 7 days Result: Inhibited activation and proliferation of astrocytes in a rat SCI model. Reduced apoptosis and promotes neuronal survival in SCI rats by TRPC6/AQP4 signaling pathway. Facilitated functional motor recovery via TRPC6/AQP4 signaling pathway in SCI rats.

[References]

[1]. Jiajun Cai, et al. Upregulation of TRPC6 inhibits astrocyte activation and proliferation after spinal cord injury in rats by suppressing AQP4 expression. Brain Res Bull. 2022 Nov;190:12-21.

Chemical & Physical Properties

[ Melting Point ]:
97 - 98 °C

[ Molecular Formula ]:
C₁₈H₂₆O₅

[ Molecular Weight ]:
322.39600

[ Exact Mass ]:
322.17800

[ PSA ]:
94.83000

[ LogP ]:
4.32940

[ Storage condition ]:
2-8°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2914400090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2914400090

[ Summary ]:
2914400090 other ketone-alcohols and ketone-aldehydes。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

TRPC6 is the endothelial calcium channel that regulates leukocyte transendothelial migration during the inflammatory response.

J. Exp. Med. 212 , 1883-99, (2015)

Leukocyte transendothelial migration (TEM) is a tightly regulated, multistep process that is critical to the inflammatory response. A transient increase in endothelial cytosolic free calcium ion conce...