Perillartine

Modify Date: 2024-01-03 09:32:47

Perillartine Structure
Perillartine structure
Common Name Perillartine
CAS Number 30950-27-7 Molecular Weight 165.232
Density 1.0±0.1 g/cm3 Boiling Point 271.4±40.0 °C at 760 mmHg
Molecular Formula C10H15NO Melting Point 102°C
MSDS N/A Flash Point 158.3±16.6 °C

 Use of Perillartine


Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.

 Names

Name Perillartine
Synonym More Synonyms

 Perillartine Biological Activity

Description Perillartine is a sweetener, which activates the taste receptor type 1 member 2 (Tas1r2) subunit in a species-dependent manner.
Related Catalog
Target

TAS1R2[1]

In Vitro The responses of the monomeric Tas1r2 subunits of human, rhesus monkey, squirrel monkey and mouse to Perillartine are examined, respectively. The human, rhesus monkey and squirrel monkey Tas1r2 subunits can be activated by Perillartine, while mouse Tas1r2 can not. The insensitivity of human, rhesus monkey, squirrel monkey and mouse Tas1r2 subunits to cyclamate precludes the probable involvement of Tas1r3 subunit in the assay. Replacement of the mouse Tas1r2 with rhesus monkey Tas1r2 (rhTas1r2/mTas1r3) leads to a gain of response to Perillartine. The dose-response curve show the efficacy of responses of the Tas1r2 subunits among species: hTAS1R2>rhTas1r2>smTas1r2>mTas1r2. These results demonstrate that the monomeric Tas1r2 subunit can be activated by Perillartine in a species-dependent manner[1].
References

[1]. Cai C, et al. Characterization of the Sweet Taste Receptor Tas1r2 from an Old World Monkey Species Rhesus Monkey and Species-Dependent Activation of the Monomeric Receptor by an Intense SweetenerPerillartine. PLoS One. 2016 Aug 1;11(8):e0160079.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 271.4±40.0 °C at 760 mmHg
Melting Point 102°C
Molecular Formula C10H15NO
Molecular Weight 165.232
Flash Point 158.3±16.6 °C
Exact Mass 165.115356
PSA 32.59000
LogP 3.33
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.513

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GW2975000
CHEMICAL NAME :
1-Cyclohexene-1-carboxaldehyde, 4-isopropenyl-, anti-oxime
CAS REGISTRY NUMBER :
30950-27-7
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H15-N-O
MOLECULAR WEIGHT :
165.26
WISWESSER LINE NOTATION :
L6UTJ A1UNQ DY1&U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74. Volume(issue)/page/year: 15,82,1951 *** REVIEWS *** TOXICOLOGY REVIEW IDJOAS International Dental Journal. (A. Sijthoff, 37 Wagenstr, The Hague, Netherlands) V.1- 1950- Volume(issue)/page/year: 23,328,1973

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36/37/39

 Synonyms

4-Isopropenyl-1-cyclohexene-1-carbaldehyde oxime
1-Cyclohexene-1-carboxaldehyde, 4- (1-methylethenyl)-, oxime
Perillartin
1-perillaldehydealpha-antioxime
4-isopropenylcyclohex-1-enecarbaldehyde oxime
l-perillaldehydealpha-syn-oxime
1-Cyclohexene-1-carboxaldehyde, 4-isopropenyl-, oxime
(E)-N-Hydroxy-1-[4-(prop-1-en-2-yl)cyclohex-1-en-1-yl]methanimine
1-Cyclohexene-1-carboxaldehyde, 4-isopropenyl-, oxime (8CI)
UNII:46S302515I
1-PERILLALDEHYDE A-ANTIOXIME
4-(1-Methylethenyl)-1-cyclohexene-1-carboxaldehyde Oxime
Perillartine
1-Cyclohexene-1-carboxaldehyde, 4-(1-methylethenyl)-, oxime
Perilla sugar
Peryllartine
(E)-N-Hydroxy-1-(4-isopropenyl-1-cyclohexen-1-yl)methanimine
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