AGK7
Modify Date: 2025-08-25 13:12:00
AGK7 structure
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Common Name | AGK7 | ||
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| CAS Number | 304896-21-7 | Molecular Weight | 434.274 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 675.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H13Cl2N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 362.1±31.5 °C | |
Use of AGK7AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1]. |
| Name | 2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-quinolin-8-ylprop-2-enamide |
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| Synonym | More Synonyms |
| Description | AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1]. |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 675.1±55.0 °C at 760 mmHg |
| Molecular Formula | C23H13Cl2N3O2 |
| Molecular Weight | 434.274 |
| Flash Point | 362.1±31.5 °C |
| Exact Mass | 433.038483 |
| PSA | 82.41000 |
| LogP | 6.77 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.718 |
| InChIKey | WRDKBSLEHFRKGG-RVDMUPIBSA-N |
| SMILES | N#CC(=Cc1ccc(-c2cc(Cl)ccc2Cl)o1)C(=O)Nc1cccc2cccnc12 |
| (2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(8-quinolinyl)acrylamide |
| 2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-, (2E)- |
| (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-8-yl)prop-2-enamide |
| (2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(quinolin-8-yl)acrylamide |
| SIRT2 Inhibitor,Inactive Control,AGK7 |