AGK7

Names

[ Name ]:
AGK7

[Synonym ]:
(2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(8-quinolinyl)acrylamide
2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-8-quinolinyl-, (2E)-
(2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-8-yl)prop-2-enamide
(2E)-2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furyl]-N-(quinolin-8-yl)acrylamide
SIRT2 Inhibitor,Inactive Control,AGK7

Biological Activity

[Description]:

AGK7 is a potent inhibitor of sirtuin 2 (SIRT2). AGK7 rescues alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. AGK7 protects against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> Sirtuin

Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin

Research Areas >> Neurological Disease

[References]

[1]. Outeiro TF, et al. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science. 2007;317(5837):516-519.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
675.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₃H₁₃Cl₂N₃O₂

[ Molecular Weight ]:
434.274

[ Flash Point ]:
362.1±31.5 °C

[ Exact Mass ]:
433.038483

[ PSA ]:
82.41000

[ LogP ]:
6.77

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.718

Safety Information

Related Compounds

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