NSC 368262
Modify Date: 2024-02-04 17:15:28
NSC 368262 structure
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Common Name | NSC 368262 | ||
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| CAS Number | 299421-08-2 | Molecular Weight | 410.426 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H22N2O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NSC 368262NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models. |
| Name | NSC 368262 |
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| Description | NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models. |
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| References | References 1. Buettner R, et al. ACS Chem Biol. 2011 May 20;6(5):432-43. View Related Products by Target STAT |
| Molecular Formula | C22H22N2O6 |
|---|---|
| Molecular Weight | 410.426 |