PHD-IN-1

Modify Date: 2024-02-25 11:13:46

PHD-IN-1 structure	Common Name	PHD-IN-1
	CAS Number	2924182-31-8	Molecular Weight	441.49
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₃N₇O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PHD-IN-1

PHD-IN-1 (compound 80) is a potent inhibitor of PHD2，with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells，respectively[1].

Name	PHD-IN-1

Description	PHD-IN-1 (compound 80) is a potent inhibitor of PHD2，with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells，respectively[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: ≤5 nM (PHD2)[1]
References	[1]. Ding X, et al. 1,7-Naphthyridine derivatives as PHD inhibitors and their preparation. World Intellectual Property Organization, WO2023072246 A1. 2023-05-04.

Molecular Formula	C₂₄H₂₃N₇O₂
Molecular Weight	441.49

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