2924182-31-8

2924182-31-8 structure

Name: PHD-IN-1
Chemical Name: PHD-IN-1
CAS Number: 2924182-31-8
Molecular Formula: C₂₄H₂₃N₇O₂
Molecular Weight: 441.49
Catalog: Signaling Pathways Metabolic Enzyme/Protease HIF/HIF Prolyl-Hydroxylase
Create Date: 2023-09-24 18:17:38
Modify Date: 2024-02-25 11:13:46
PHD-IN-1 (compound 80) is a potent inhibitor of PHD2，with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells，respectively[1].

Name	PHD-IN-1

Description	PHD-IN-1 (compound 80) is a potent inhibitor of PHD2，with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells，respectively[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase
Target	IC50: ≤5 nM (PHD2)[1]
References	[1]. Ding X, et al. 1,7-Naphthyridine derivatives as PHD inhibitors and their preparation. World Intellectual Property Organization, WO2023072246 A1. 2023-05-04.

Molecular Formula	C₂₄H₂₃N₇O₂
Molecular Weight	441.49