PHD-IN-1

Names

[ CAS No. ]:
2924182-31-8

[ Name ]:
PHD-IN-1

Biological Activity

[Description]:

PHD-IN-1 (compound 80) is a potent inhibitor of PHD2，with an IC50 value of ≤5 nM. PHD-IN-1 shows EC50s of 2.5 μM in EPO Elisa assay both in Caco2-HIFla-HiBiT-clone-1 cells and Hep3B cells，respectively[1].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase

[Target]

IC50: ≤5 nM (PHD2)[1]


[References]

[1]. Ding X, et al. 1,7-Naphthyridine derivatives as PHD inhibitors and their preparation. World Intellectual Property Organization, WO2023072246 A1. 2023-05-04.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H23N7O2

[ Molecular Weight ]:
441.49

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.