AcrB-IN-1

Modify Date: 2025-09-28 19:15:10

AcrB-IN-1 Structure
AcrB-IN-1 structure
 Common Name AcrB-IN-1
CAS Number 2890177-82-7 Molecular Weight 529.67
Density N/A Boiling Point N/A
Molecular Formula C32H39N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AcrB-IN-1


AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance[1].

 Names

Name AcrB-IN-1

 AcrB-IN-1 Biological Activity

Description AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance[1].
Related Catalog
In Vitro AcrB-IN-1 (Compound H6) 能在亚 MIC 浓度 (8-128 μg/mL) 下降低所测抗菌药物 (Erythromycin HY-B0220, Levofloxacin HY-B0330, Minocycline HY-17412A) 对大肠杆菌 BW25113 的 MIC 值[1]。 AcrB-IN-1 (64 μg/mL) 不破坏细菌内膜[1]。 AcrB-IN-1 在浓度为 50 μM 时完全消除尼罗河红 (已知的 AcrB 底物) 外排[1]。
References

[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.  

 Chemical & Physical Properties

Molecular Formula C32H39N3O4
Molecular Weight 529.67
InChIKey XXCDSWYDXQITBG-UHFFFAOYSA-N
SMILES CC1(C)CCc2c(C(=O)N3CCOCC3)cc3c(OCCN4CCN(c5ccccc5)CC4)cccc3c2O1
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2-((1-ethyl-6-(furan-2-ylmethyl)-3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)-N-(3-(methylthio)phenyl)acetamide
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methyl 4-[2-({1-ethyl-6-[(furan-2-yl)methyl]-3-methyl-7-oxo-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-5-yl}sulfanyl)acetamido]benzoate
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N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-((1-ethyl-6-(furan-2-ylmethyl)-3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)acetamide
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N-(4-ethoxyphenyl)-2-((1-ethyl-6-(furan-2-ylmethyl)-3-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thio)acetamide
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5-((4-chlorobenzyl)thio)-1-ethyl-6-(furan-2-ylmethyl)-3-methyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one
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1-ethyl-6-[(furan-2-yl)methyl]-3-methyl-5-{[(3-methylphenyl)methyl]sulfanyl}-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one
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Chemsrc provides AcrB-IN-1(CAS#:2890177-82-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of AcrB-IN-1 are included as well.>> amp version: AcrB-IN-1

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