2890177-82-7

2890177-82-7 structure
2890177-82-7 structure
  • Name: AcrB-IN-1
  • Chemical Name: AcrB-IN-1
  • CAS Number: 2890177-82-7
  • Molecular Formula: C32H39N3O4
  • Molecular Weight: 529.67
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2023-09-09 09:42:30
  • Modify Date: 2024-09-23 10:05:54
  • AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance[1].

Name AcrB-IN-1
Description AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance[1].
Related Catalog
In Vitro AcrB-IN-1 (Compound H6) 能在亚 MIC 浓度 (8-128 μg/mL) 下降低所测抗菌药物 (Erythromycin HY-B0220, Levofloxacin HY-B0330, Minocycline HY-17412A) 对大肠杆菌 BW25113 的 MIC 值[1]。 AcrB-IN-1 (64 μg/mL) 不破坏细菌内膜[1]。 AcrB-IN-1 在浓度为 50 μM 时完全消除尼罗河红 (已知的 AcrB 底物) 外排[1]。
References

[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.  

Molecular Formula C32H39N3O4
Molecular Weight 529.67
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