AcrB-IN-1

Names

[ Name ]:
AcrB-IN-1

Biological Activity

[Description]:

AcrB-IN-1 (Compound H6) is a potent AcrB inhibitor. AcrB-IN-1 can be used for the reversal of bacterial multidrug resistance[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

AcrB-IN-1 (Compound H6) 能在亚 MIC 浓度 (8-128 μg/mL) 下降低所测抗菌药物 (Erythromycin HY-B0220, Levofloxacin HY-B0330, Minocycline HY-17412A) 对大肠杆菌 BW25113 的 MIC 值[1]。 AcrB-IN-1 (64 μg/mL) 不破坏细菌内膜[1]。 AcrB-IN-1 在浓度为 50 μM 时完全消除尼罗河红 (已知的 AcrB 底物) 外排[1]。

[References]

[1]. Guo T, et al. Design and synthesis of benzochromene derivatives as AcrB inhibitors for the reversal of bacterial multidrug resistance. Eur J Med Chem. 2023 Mar 5;249:115148.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₃₉N₃O₄

[ Molecular Weight ]:
529.67

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.