Thymidine 3',5'-disphosphate

Modify Date: 2024-01-22 12:01:19

Thymidine 3',5'-disphosphate Structure
Thymidine 3',5'-disphosphate structure
Common Name Thymidine 3',5'-disphosphate
CAS Number 2863-04-9 Molecular Weight 402.19
Density N/A Boiling Point N/A
Molecular Formula C10H16N2O11P2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thymidine 3',5'-disphosphate


Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of SND1 (the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3',5'-disphosphate is an anti-HCC agent and exhibits anti-tumor efficacy in vivo[1].

 Names

Name Thymidine 3',5'-diphosphate
Synonym More Synonyms

 Thymidine 3',5'-disphosphate Biological Activity

Description Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of SND1 (the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3',5'-disphosphate is an anti-HCC agent and exhibits anti-tumor efficacy in vivo[1].
Related Catalog
Target

IC50: SND1[1]

References

[1]. Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316.

[2]. Byoung Kwon Yoo, et al. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology. 2011 May;53(5):1538-48.

 Chemical & Physical Properties

Molecular Formula C10H16N2O11P2
Molecular Weight 402.19
Exact Mass 402.02300
PSA 217.23000

 Safety Information

Hazard Codes Xi

 Synonyms

thymidine-3',5'-diphosphate