Thymidine 3',5'-disphosphate

Names

[ Name ]:
Thymidine 3',5'-disphosphate

[Synonym ]:
thymidine-3',5'-diphosphate

Biological Activity

[Description]:

Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of SND1 (the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3',5'-disphosphate is an anti-HCC agent and exhibits anti-tumor efficacy in vivo[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

IC50: SND1[1]

[References]

[1]. Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316.

[2]. Byoung Kwon Yoo, et al. Increased RNA-induced silencing complex (RISC) activity contributes to hepatocellular carcinoma. Hepatology. 2011 May;53(5):1538-48.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₀H₁₆N₂O₁₁P₂

[ Molecular Weight ]:
402.19

[ Exact Mass ]:
402.02300

[ PSA ]:
217.23000

Safety Information

[ Hazard Codes ]:
Xi

Thymidine 3',5'-disphosphate

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds