QR-6401

Modify Date: 2025-08-27 11:19:51

QR-6401 structure	Common Name	QR-6401
	CAS Number	2845096-18-4	Molecular Weight	369.42
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₂₃N₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of QR-6401

QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].

Name	QR-6401

Description	QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. Yu Y, et al. Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. ACS Med Chem Lett. 2023 Feb 8;14(3):297-304.

Molecular Formula	C₁₉H₂₃N₅O₃
Molecular Weight	369.42

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QR-6401

Use of QR-6401

Names

QR-6401 Biological Activity

Chemical & Physical Properties

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.