QR-6401

Names

[ CAS No. ]:
2845096-18-4

[ Name ]:
QR-6401

Biological Activity

[Description]:

QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> CDK

[References]

[1]. Yu Y, et al. Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. ACS Med Chem Lett. 2023 Feb 8;14(3):297-304.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H23N5O3

[ Molecular Weight ]:
369.42

Related Compounds

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