2845096-18-4

2845096-18-4 structure

Name: QR-6401
Chemical Name: QR-6401
CAS Number: 2845096-18-4
Molecular Formula: C₁₉H₂₃N₅O₃
Molecular Weight: 369.42
Catalog: Signaling Pathways Cell Cycle/DNA Damage CDK
Create Date: 2023-09-28 17:27:51
Modify Date: 2024-01-02 08:19:45
QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].

Name	QR-6401

Description	QR-6401 is an orally active and selective macrocyclic CDK2 inhibitor with IC50 values of 0.37, 10, 22, 34 and 45 nM for CDK2/E1, CDK9/T1, CDK1/A2, CDK6/D3 and CDK4/D1, respectively. QR-6401 has potent antitumor activity in an OVCAR3 ovarian cancer xenograft model. QR-6401 has the potential to be used in the study of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
References	[1]. Yu Y, et al. Accelerated Discovery of Macrocyclic CDK2 Inhibitor QR-6401 by Generative Models and Structure-Based Drug Design. ACS Med Chem Lett. 2023 Feb 8;14(3):297-304.

Molecular Formula	C₁₉H₂₃N₅O₃
Molecular Weight	369.42