Ro 64-6198
Modify Date: 2025-08-25 12:36:56
Ro 64-6198 structure
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Common Name | Ro 64-6198 | ||
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| CAS Number | 280783-56-4 | Molecular Weight | 401.544 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 626.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H31N3O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 332.5±31.5 °C | |
Use of Ro 64-6198Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued |
| Name | Ro64-6198 |
|---|---|
| Synonym | More Synonyms |
| Description | Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued |
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| References | References 1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64. 2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23. 3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43. View Related Products by Target Opioid Receptor Anxiety |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 626.2±55.0 °C at 760 mmHg |
| Molecular Formula | C26H31N3O |
| Molecular Weight | 401.544 |
| Flash Point | 332.5±31.5 °C |
| Exact Mass | 401.246704 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.668 |
| InChIKey | JLFMYEAXZNPWBK-REWPJTCUSA-N |
| SMILES | O=C1NCN(c2ccccc2)C12CCN(C1CCC3CCCc4cccc1c43)CC2 |
| 1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl- |
| Ro64-6198 |
| 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |