280783-56-4
280783-56-4 structure
- Name: Ro 64-6198
- Chemical Name: Ro64-6198
- CAS Number: 280783-56-4
- Molecular Formula: C26H31N3O
- Molecular Weight: 401.544
- Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
- Create Date: 2020-01-14 19:22:14
- Modify Date: 2024-01-04 10:37:43
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Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued
| Name | Ro64-6198 |
|---|---|
| Synonyms |
1,3,8-Triazaspiro[4.5]decan-4-one, 8-[(1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl]-1-phenyl-
Ro64-6198 8-[(1S,3aS)-2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one |
| Description | Ro 64-6198 is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41; displays >100-fold selectivity for ORL1 over other members of opioid receptor family; elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.). Anxiety Discontinued |
|---|---|
| References | References 1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64. 2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23. 3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43. View Related Products by Target Opioid Receptor Anxiety |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 626.2±55.0 °C at 760 mmHg |
| Molecular Formula | C26H31N3O |
| Molecular Weight | 401.544 |
| Flash Point | 332.5±31.5 °C |
| Exact Mass | 401.246704 |
| LogP | 3.72 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.668 |