PhTX-433
PhTX-433 structure
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Common Name | PhTX-433 | ||
|---|---|---|---|---|
| CAS Number | 276684-27-6 | Molecular Weight | 777.67300 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H44F9N5O9 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of PhTX-433PhTX-433, also known as Philanthotoxin 433, is a polyamine-containing toxin, which blocks NMDA-gated ion channels; originally isolated from the venom of the wasp Philanthus triangulum. |
| Name | N-[(2S)-1-[4-[3-(3-aminopropylamino)propylamino]butylamino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]butanamide,2,2,2-trifluoroacetic acid |
|---|---|
| Synonym | More Synonyms |
| Molecular Formula | C29H44F9N5O9 |
|---|---|
| Molecular Weight | 777.67300 |
| Exact Mass | 777.30000 |
| PSA | 247.39000 |
| LogP | 6.09670 |
| InChIKey | VZYCSHPEJIBNPQ-BOXHHOBZSA-N |
| SMILES | CCCC(=O)NC(Cc1ccc(O)cc1)C(=O)NCCCCNCCCNCCCN.O=C(O)C(F)(F)F |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| RIDADR | UN 2811 6.1/PG 2 |
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Effects of philanthotoxin-343 on CA1 pyramidal neurons of rat hippocampus in vitro.
Eur. J. Pharmacol. 228 , 201-206, (1992) A synthetic analog of philanthotoxin-433, philanthotoxin-343 (PhTX-343), was tested in hippocampal pyramidal neurons in vitro. PhTX-343 (2 microM) did not significantly change synaptic transmission me... |
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Philanthotoxin inhibits Ca2+ currents in rat hippocampal CA1 neurons.
Eur. J. Pharmacol. 270 , 357-360, (1994) The wasp venom philanthotoxin-4.3.3 (PhTX-4.3.3) is an antagonist of glutamate transmission in the insect as well as in the mammalian brain. It was recently shown that PhTX-4.3.3 inhibits the N-methyl... |
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Inhibition of dipteran larval neuromuscular synaptic transmission by analogues of philanthotoxin-4.3.3: a structure-activity study.
Comp. Biochem. Physiol. 102C , 267-272, (1992) 1. The blocking action of delta-philanthotoxin (PhTX-4.3.3), a wasp toxin composed of a polyamine chain, an aromatic amino acid (tyrosyl) nucleus and an aliphatic (butanoic) acid was studied, together... |
| (S)-N-[4-[[3-[(3-Aminopropyl)amino]propyl]amino]butyl]-4-hydroxy-|A-[(1-oxobutyl)amino]benzenepropanamide tris(trifluoroacetate) salt |
| Philanthotoxin 433 tris(trifluoroacetate) salt |
| PhTX-433 tris(trifluoroacetate) salt |