PhTX-433
Names
[ CAS No. ]:
276684-27-6
[ Name ]:
PhTX-433
[Synonym ]:
(S)-N-[4-[[3-[(3-Aminopropyl)amino]propyl]amino]butyl]-4-hydroxy-|A-[(1-oxobutyl)amino]benzenepropanamide tris(trifluoroacetate) salt
Philanthotoxin 433 tris(trifluoroacetate) salt
PhTX-433 tris(trifluoroacetate) salt
Chemical & Physical Properties
[ Molecular Formula ]:
C29H44F9N5O9
[ Molecular Weight ]:
777.67300
[ Exact Mass ]:
777.30000
[ PSA ]:
247.39000
[ LogP ]:
6.09670
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301
[ Precautionary Statements ]:
P301 + P310
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ RIDADR ]:
UN 2811 6.1/PG 2
Articles
Eur. J. Pharmacol. 228 , 201-206, (1992)
A synthetic analog of philanthotoxin-433, philanthotoxin-343 (PhTX-343), was tested in hippocampal pyramidal neurons in vitro. PhTX-343 (2 microM) did not significantly change synaptic transmission me...
Philanthotoxin inhibits Ca2+ currents in rat hippocampal CA1 neurons.Eur. J. Pharmacol. 270 , 357-360, (1994)
The wasp venom philanthotoxin-4.3.3 (PhTX-4.3.3) is an antagonist of glutamate transmission in the insect as well as in the mammalian brain. It was recently shown that PhTX-4.3.3 inhibits the N-methyl...
Inhibition of dipteran larval neuromuscular synaptic transmission by analogues of philanthotoxin-4.3.3: a structure-activity study.Comp. Biochem. Physiol. 102C , 267-272, (1992)
1. The blocking action of delta-philanthotoxin (PhTX-4.3.3), a wasp toxin composed of a polyamine chain, an aromatic amino acid (tyrosyl) nucleus and an aliphatic (butanoic) acid was studied, together...