LE 300
Modify Date: 2025-08-24 18:12:00
LE 300 structure
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Common Name | LE 300 | ||
|---|---|---|---|---|
| CAS Number | 274694-98-3 | Molecular Weight | 290.40200 | |
| Density | 1.114g/cm3 | Boiling Point | 464ºC at 760 mmHg | |
| Molecular Formula | C20H22N2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 234.4ºC | |
Use of LE 300LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2]. |
| Name | le 300 |
|---|---|
| Synonym | More Synonyms |
| Description | LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2]. |
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| Related Catalog | |
| Target |
Human D1 Receptor:1.9 nM (Ki) Human D5 Receptor:7.5 nM (Ki) Rat 5-HT2A:8.32 (pA2) |
| References |
| Density | 1.114g/cm3 |
|---|---|
| Boiling Point | 464ºC at 760 mmHg |
| Molecular Formula | C20H22N2 |
| Molecular Weight | 290.40200 |
| Flash Point | 234.4ºC |
| Exact Mass | 290.17800 |
| PSA | 19.03000 |
| LogP | 3.72700 |
| Vapour Pressure | 8.69E-09mmHg at 25°C |
| Index of Refraction | 1.63 |
| InChIKey | YEWGIGCYIAMFMA-UHFFFAOYSA-N |
| SMILES | CN1CCc2ccccc2Cc2[nH]c3ccccc3c2CC1 |
| Tocris-1674 |
| Lopac-L-8401 |