Top Suppliers:I want be here
  • DC Chemicals Limited
  • China
  • Product Name: LE 300
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

274694-98-3

274694-98-3 structure
274694-98-3 structure
  • Name: LE 300
  • Chemical Name: le 300
  • CAS Number: 274694-98-3
  • Molecular Formula: C20H22N2
  • Molecular Weight: 290.40200
  • Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
  • Create Date: 2016-02-12 08:35:10
  • Modify Date: 2024-01-03 09:32:08
  • LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].

Name le 300
Synonyms Tocris-1674
Lopac-L-8401
Description LE 300 is a potent and selective dopamine D1-like receptor antagonist with Kis of 1.9 nM and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively. LE 300 is an antagonist of the 5-HT2A receptor with a pA2 of 8.32 in a rat tail artery assay[1][2].
Related Catalog
Target

Human D1 Receptor:1.9 nM (Ki)

Human D5 Receptor:7.5 nM (Ki)

Rat 5-HT2A:8.32 (pA2)

References

[1]. Kassack MU, et al. Pharmacological characterization of the benz[d]indolo[2,3-g]azecine LE300, a novel type of a nanomolar dopamine receptor antagonist. Naunyn Schmiedebergs Arch Pharmacol. 2002 Dec;366(6):543-50.

[2]. Rostom SA. Novel fused pyrrole heterocyclic ring systems as structure analogs of LE 300: Synthesis and pharmacological evaluation as serotonin 5-HT(2A), dopamine and histamine H(1) receptor ligands. Arch Pharm (Weinheim). 2010 Feb;343(2):73-80.

Density 1.114g/cm3
Boiling Point 464ºC at 760 mmHg
Molecular Formula C20H22N2
Molecular Weight 290.40200
Flash Point 234.4ºC
Exact Mass 290.17800
PSA 19.03000
LogP 3.72700
Vapour Pressure 8.69E-09mmHg at 25°C
Index of Refraction 1.63