1-(bis(4-fluorophenyl)methyl)piperazine

Modify Date: 2024-01-08 12:23:02

1-(bis(4-fluorophenyl)methyl)piperazine Structure
1-(bis(4-fluorophenyl)methyl)piperazine structure
 Common Name 1-(bis(4-fluorophenyl)methyl)piperazine
CAS Number 27469-60-9 Molecular Weight 288.335
Density 1.2±0.1 g/cm3 Boiling Point 367.9±37.0 °C at 760 mmHg
Molecular Formula C17H18F2N2 Melting Point 88-92 °C(lit.)
MSDS N/A Flash Point 176.3±26.5 °C
Symbol GHS06
GHS06		 Signal Word Danger

 Names

Name 1-[bis(4-fluorophenyl)methyl]piperazine
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 367.9±37.0 °C at 760 mmHg
Melting Point 88-92 °C(lit.)
Molecular Formula C17H18F2N2
Molecular Weight 288.335
Flash Point 176.3±26.5 °C
Exact Mass 288.143799
PSA 15.27000
LogP 2.95
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.560
Water Solubility 0.34 g/L (20 ºC)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H315-H319-H335
Precautionary Statements P261-P301 + P310-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic
Risk Phrases R25;R36/37/38
Safety Phrases S26-S45-S36/37/39
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
Packaging Group I; II; III
Hazard Class 6.1

 Synthetic Route

Piperazine structure

Piperazine

CAS#:110-85-0

4,4'-Difluorodiphenylmethylchloride structure

4,4'-Difluorodi...

CAS#:27064-94-4

~%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Weiwer, Michel; Bittker, Joshua A.; Lewis, Timothy A.; Shimada, Kenichi; Yang, Wan Seok; MacPherson, Lawrence; Dandapani, Sivaraman; Palmer, Michelle; Stockwell, Brent R.; Schreiber, Stuart L.; Munoz, Benito Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 4 p. 1822 - 1826
N/A structure

N/A

CAS#:156640-07-2

~70%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Valenta, Vladimir; Urban, Jiri; Taimr, Jan; Polivka, Zdenek Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 5 p. 1126 - 1136
4,4'-Diflurobenzylmethanol structure

4,4'-Difluroben...

CAS#:365-24-2

~%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Gurdal, Enise Ece; Durmaz, Irem; Cetin-Atalay, Rengul; Yarim, Mine Journal of Enzyme Inhibition and Medicinal Chemistry, 2014 , vol. 29, # 2 p. 205 - 214
4,4′-difluorobenzophenone structure

4,4′-difluorobe...

CAS#:345-92-6

~%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Shivprakash; Reddy, G. Chandrasekara Synthetic Communications, 2014 , vol. 44, # 5 p. 600 - 609
4,4'-Difluorodiphenylmethylchloride structure

4,4'-Difluorodi...

CAS#:27064-94-4

piperazine dihydrochloride structure

piperazine dihy...

CAS#:142-64-3

~%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Santhoshi, Amlipur; Kumar, Singam Naveen; Sujitha, Pombala; Poornachandra, Yedla; Sadhu, Partha Sarathi; Kumar, C. Ganesh; Rao, Vaidya Jayathirtha Medicinal Chemistry Research, 2014 , vol. 23, # 6 p. 3207 - 3219
4,4'-Difluorodiphenylmethylchloride structure

4,4'-Difluorodi...

CAS#:27064-94-4

~%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Valenta, Vladimir; Urban, Jiri; Taimr, Jan; Polivka, Zdenek Collection of Czechoslovak Chemical Communications, 1994 , vol. 59, # 5 p. 1126 - 1136
Piperazine structure

Piperazine

CAS#:110-85-0

1,1'-(Bromomethylene)bis(4-fluorobenzene) structure

1,1'-(Bromometh...

CAS#:345-90-4

~%

1-(bis(4-fluorophenyl)methyl)piperazine Structure

1-(bis(4-fluoro...

CAS#:27469-60-9

Literature: Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M. European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250

 Articles2

More Articles
Oxidative metabolism of flunarizine in rat liver microsomes.

Res. Commun. Chem. Pathol. Pharmacol. 78(1) , 85-95, (1992)

The oxidative metabolism of flunarizine [1-[bis(4-fluorophenyl)-methyl]-4-(3-phenyl-2-propenyl)piperazine, FZ] to 1-[bis-(4-fluorophenyl)methyl]piperazine (M-1), 1-[bis(4-fluorophenyl)methyl]-4-[3-(4'...

Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite.

Arch. Toxicol. 69(6) , 391-6, (1995)

Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appe...

 Synonyms

N-[bis(4-fluorophenyl)methyl]piperazine
1-(4,4'-Difluorodiphenylmethyl)piperazine
4,4'-Difluorobenzhydrylpiperazine
1-[Bis-(4-fluorophenyl)methyl]piperazine
1-[(4',4''-difluorodiphenyl)methyl]piperazine
MFCD00038660
1 [bis(4-Fluorophenyl)methyl]-piperazine
1-[Bis(4-fluorophenyl)methyl]piperazine
1-(4,4'-Difluorobenzhydryl)piperazine
1-(bis(4-fluorophenyl)methyl)piperazine
[bis(4-fluorophenyl)methyl]piperazine
1-Bis(4-fluorophenyl)methyl piperazine
Piperazine, 1-[bis(4-fluorophenyl)methyl]-
1-[bis-(p-fluorophenyl)methyl]piperazine
EINECS 248-476-0
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