New xanthine derivatives with potent and long lasting anti-bronchoconstrictive activity

…, FP Tisserand, G Saint-Romas, SM Holstorp

Index: Regnier, Gilbert L.; Guillonneau, Claude G.; Duhault, Jacques L.; Tisserand, Francoise P.; Saint-Romas, Guy; Holstorp, Sophie M. European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 243 - 250

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Citation Number: 16

Abstract

Abstract Twenty eight new derivatives of 8-aminoalkyl substituted xanthine have been synthesized. They all have demonstrated a potent anti-bronchoconstrictive effect in the guinea pig and some of them have a very long duration of action (> 48 h). Among them, one compound: 1-methyl 3-isobutyl 8-(4-benzhydryl piperazino ethyl) xanthine (57)(S 9795) has been selected for clinical trials in asthmatic patients because of its long duration of action, ...