Deoxyneocryptotanshinone

Modify Date: 2024-01-17 17:59:24

Deoxyneocryptotanshinone structure	Common Name	Deoxyneocryptotanshinone
	CAS Number	27468-20-8	Molecular Weight	298.376
	Density	1.2±0.1 g/cm3	Boiling Point	468.0±45.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₂O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	251.0±25.2 °C

Use of Deoxyneocryptotanshinone

Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].

Name	Deoxyneocryptotanshinone
Synonym	More Synonyms

Description	Deoxyneocryptotanshinone, a natural tanshinone, is a high affinity BACE1 (Beta-secretase) inhibitor with an IC50 value of 11.53 μM. Deoxyneocryptotanshinone shows a promising dose-dependent inhibition of protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 133.5 μM. Deoxyneocryptotanshinone can be used for Alzheimer's disease research[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase Research Areas >> Neurological Disease
Target	IC50: 11.53 μM (BACE1)[1] and 133.5 μM (PTP1B)[2]
References	[1]. Ting Yu, et al. Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations. Comput Biol Chem. 2018 Jun;74:273-285. [2]. Da Hye Kim, et al. Characterization of the inhibitory activity of natural tanshinones from Salvia miltiorrhiza roots on protein tyrosine phosphatase 1B. Chem Biol Interact. 2017 Dec 25;278:65-73.

Density	1.2±0.1 g/cm3
Boiling Point	468.0±45.0 °C at 760 mmHg
Molecular Formula	C₁₉H₂₂O₃
Molecular Weight	298.376
Flash Point	251.0±25.2 °C
Exact Mass	298.156891
PSA	54.37000
LogP	5.74
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.583