Coumarone

Modify Date: 2024-01-02 19:48:34

Coumarone structure	Common Name	Coumarone
	CAS Number	271-89-6	Molecular Weight	118.133
	Density	1.1±0.1 g/cm3	Boiling Point	174.0±0.0 °C at 760 mmHg
	Molecular Formula	C₈H₆O	Melting Point	-18ºC
	MSDS	Chinese USA	Flash Point	56.1±0.0 °C
	Symbol	GHS02, GHS08	Signal Word	Warning

Name	1-benzofuran
Synonym	More Synonyms

Density	1.1±0.1 g/cm3
Boiling Point	174.0±0.0 °C at 760 mmHg
Melting Point	-18ºC
Molecular Formula	C₈H₆O
Molecular Weight	118.133
Flash Point	56.1±0.0 °C
Exact Mass	118.041862
PSA	13.14000
LogP	2.67
Vapour Pressure	1.7±0.3 mmHg at 25°C
Index of Refraction	1.600
Water Solubility	insoluble

Coumarone MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DF6423800

CHEMICAL NAME :: Benzofuran

CAS REGISTRY NUMBER :: 271-89-6

BEILSTEIN REFERENCE NO. :: 0107704

LAST UPDATED :: 199710

DATA ITEMS CITED :: 19

MOLECULAR FORMULA :: C8-H6-O

MOLECULAR WEIGHT :: 118.14

WISWESSER LINE NOTATION :: T56 BOJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 7 gm/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 16250 mg/kg/13W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Kidney, Ureter, Bladder - changes in both tubules and glomeruli

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32500 mg/kg/13W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 437 mg/kg/14D-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 61800 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Kidney, Ureter, Bladder - Kidney tumors

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30900 mg/kg/2Y-C

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Gastrointestinal - tumors Liver - tumors

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 199 mg/L

REFERENCE :: NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-370,1989 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 63,431,1995 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3271 No. of Facilities: 40 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 111 (estimated)

Symbol	GHS02, GHS08
Signal Word	Warning
Hazard Statements	H226-H351-H412
Precautionary Statements	P273-P281
Hazard Codes	Xn:Harmful
Risk Phrases	R10;R40
Safety Phrases	S36/37-S16
RIDADR	UN 1993 3/PG 3
WGK Germany	3
RTECS	DF6423800
Packaging Group	III
Hazard Class	3
HS Code	29329900

Precursor 9
CAS#:496-41-3 Benzofuran-2-ca... CAS#:6280-80-4 2-(2-Formylphen... CAS#:166975-76-4 4-(2-PIPERIDINO... CAS#:73867-48-8 6-methoxy-2-(2-...
CAS#:59214-70-9 3-Bromobenzofuran CAS#:91703-34-3 Phenol, 2-(2,2-... CAS#:199010-94-1 (2-ethynylpheno... CAS#:91-64-5 Coumarin
CAS#:496-16-2 Coumaran
DownStream 10
CAS#:496-41-3 Benzofuran-2-ca... CAS#:3131-63-3 2-Ethylbenzofuran CAS#:33094-66-5 Benzofuran, 2-nitro- CAS#:75420-78-9 Benzofuran,3-nitro-
CAS#:69-72-7 Salicylic acid CAS#:4265-27-4 2-Butyl-benzofuran CAS#:4265-25-2 2-Methylbenzofuran CAS#:5101-44-0 2-Ethynyl-phenol
CAS#:3782-00-1 2,3-dimethylben... CAS#:41717-32-2 BENZOFURAN-2-CA...

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Rational design of novel CYP2A6 inhibitors.

Bioorg. Med. Chem. 22(23) , 6655-64, (2015)

Inhibition of CYP2A6-mediated nicotine metabolism can reduce cigarette smoking. We sought potent and selective CYP2A6 inhibitors to be used as leads for drugs useful in smoking reduction therapy, by e...

Cyclooxygenase 2 inhibitor celecoxib inhibits glutamate release by attenuating the PGE2/EP2 pathway in rat cerebral cortex endings.

J. Pharmacol. Exp. Ther. 351(1) , 134-45, (2014)

The excitotoxicity caused by excessive glutamate is a critical element in the neuropathology of acute and chronic brain disorders. Therefore, inhibition of glutamate release is a potentially valuable ...

Targeting kidney CLC-K channels: pharmacological profile in a human cell line versus Xenopus oocytes.

Biochim. Biophys. Acta 1838(10) , 2484-91, (2014)

CLC-K chloride channels play a crucial role in kidney physiology and genetic mutations, affecting their function are responsible for severe renal salt loss in humans. Thus, compounds that selectively ...

Coumarone

4-Chlorosulfonyl-2,1,3-benzothiadiazole

MFCD00005847

2,1,3-benzothiadiazole-4-sulfonylchloride

Benzo<a>pyrene

Benzo-2,1,3-thiadiazole-4-sulphonyl chloride

2,3-Benzofuran

EINECS 205-982-6

2,1,3-benzothiadiazol-4-sulfonyl chloride

1-Benzofuran

Benzofuran

benzofuran-

2,1,3-Benzothiadiazole,4-chlorosulfonyl

3,4-benzopyrene

2,3,4-TRIFLUOROBENZENEETHANOL

benzo[b]furan

2,1,3-benzothiadiazole-4-sulphonyl chloride

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Coumarone
Price: ￥188.0/100g ￥98.0/25g
Purity: 99.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Benzofuran
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Benzofuran Cas NO. 271-89-6
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

Get all suppliers and price by the below link:

Coumarone suppliers

Coumarone price

Coumarone

Names

Chemical & Physical Properties

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

Safety Information

Synthetic Route

Precursor & DownStream

Customs

Articles3

Synonyms