Alamethicin

Modify Date: 2024-01-09 10:12:33

Alamethicin Structure
Alamethicin structure
Common Name Alamethicin
CAS Number 27061-78-5 Molecular Weight 1964.31000
Density N/A Boiling Point N/A
Molecular Formula C92H150N22O25 Melting Point 255-270ºC
MSDS Chinese USA Flash Point 188.6 °F
Symbol GHS06
GHS06
Signal Word Danger

 Use of Alamethicin


Alamethicin, isolated from Trichoderma viride, is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes[1][2].

 Names

Name Alamethicin
Synonym More Synonyms

 Alamethicin Biological Activity

Description Alamethicin, isolated from Trichoderma viride, is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes[1][2].
Related Catalog
References

[1]. Rindfleisch H, et al. Biosynthesis of alamethicin. FEBS Lett. 1976 Mar 1;62(3):276-80.

[2]. Olga S.Ostroumova, et al. Chapter Six - Modifiers of Membrane Dipole Potentials as Tools for Investigating Ion Channel Formation and Functioning. International Review of Cell and Molecular Biology Volume 315, 2015, Pages 245-297.

 Chemical & Physical Properties

Melting Point 255-270ºC
Molecular Formula C92H150N22O25
Molecular Weight 1964.31000
Exact Mass 1963.11000
PSA 708.13000
LogP 3.96740
Storage condition -20°C

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T+
Risk Phrases R25
RIDADR UN 3462 6
Flash Point(F) 188.6 °F
Flash Point(C) 87 °C

 Articles39

More Articles
The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels.

Biochim. Biophys. Acta 1778(12) , 2814-22, (2008)

We examined the permeabilization of lipid bilayers by the beta-sheet, cyclic antimicrobial decapeptide gramicidin S (GS) in phospholipid bilayers formed either by mixtures of zwitterionic diphytanoylp...

Interaction of the antibiotic minocycline with liver mitochondria - role of membrane permeabilization in the impairment of respiration.

FEBS J. 280(24) , 6589-99, (2013)

Several studies have proposed that the antibiotic minocycline (MC) has cytoprotective activities. Nevertheless, when cells have been exposed to MC at micromolar concentrations, detrimental effects hav...

ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT.

Drug Metab. Dispos. 40(11) , 2081-9, (2012)

We have suggested that adenine-related compounds are allosteric inhibitors of UGT in rat liver microsomes (RLM) treated with detergent. To clarify whether the same occurs with a pore-forming peptide, ...

 Synonyms

alamethicin from trichoderma viride
MFCD00151517
ALAMETHICINRESEARCH GRADE
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