Alamethicin
Alamethicin structure
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Common Name | Alamethicin | ||
|---|---|---|---|---|
| CAS Number | 27061-78-5 | Molecular Weight | 1964.31000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C92H150N22O25 | Melting Point | 255-270ºC | |
| MSDS | Chinese USA | Flash Point | 188.6 °F | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of AlamethicinAlamethicin, isolated from Trichoderma viride, is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes[1][2]. |
| Name | Alamethicin |
|---|---|
| Synonym | More Synonyms |
| Description | Alamethicin, isolated from Trichoderma viride, is a channel-forming peptide antibiotic and induces voltage-gated conductance in model and cell membranes[1][2]. |
|---|---|
| Related Catalog | |
| References |
[1]. Rindfleisch H, et al. Biosynthesis of alamethicin. FEBS Lett. 1976 Mar 1;62(3):276-80. |
| Melting Point | 255-270ºC |
|---|---|
| Molecular Formula | C92H150N22O25 |
| Molecular Weight | 1964.31000 |
| Exact Mass | 1963.11000 |
| PSA | 708.13000 |
| LogP | 3.96740 |
| InChIKey | LGHSQOCGTJHDIL-UTXLBGCNSA-N |
| SMILES | CC(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C)(C)C(=O)NC(C)C(=O)NC(C)(C)C(=O)NC(C)C(=O)NC(CCC(N)=O)C(=O)NC(C)(C)C(=O)NC(C(=O)NC(C)(C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)(C)C(=O)N1CCCC1C(=O)NC(C(=O)NC(C)(C)C(=O)NC(C)(C)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(N)=O)C(=O)NC(CO)Cc1ccccc1)C(C)C)C(C)C |
| Storage condition | -20°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+ |
| Risk Phrases | R25 |
| RIDADR | UN 3462 6 |
| Flash Point(F) | 188.6 °F |
| Flash Point(C) | 87 °C |
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The antimicrobial peptide gramicidin S permeabilizes phospholipid bilayer membranes without forming discrete ion channels.
Biochim. Biophys. Acta 1778(12) , 2814-22, (2008) We examined the permeabilization of lipid bilayers by the beta-sheet, cyclic antimicrobial decapeptide gramicidin S (GS) in phospholipid bilayers formed either by mixtures of zwitterionic diphytanoylp... |
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Interaction of the antibiotic minocycline with liver mitochondria - role of membrane permeabilization in the impairment of respiration.
FEBS J. 280(24) , 6589-99, (2013) Several studies have proposed that the antibiotic minocycline (MC) has cytoprotective activities. Nevertheless, when cells have been exposed to MC at micromolar concentrations, detrimental effects hav... |
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ATP serves as an endogenous inhibitor of UDP-glucuronosyltransferase (UGT): a new insight into the latency of UGT.
Drug Metab. Dispos. 40(11) , 2081-9, (2012) We have suggested that adenine-related compounds are allosteric inhibitors of UGT in rat liver microsomes (RLM) treated with detergent. To clarify whether the same occurs with a pore-forming peptide, ... |
| alamethicin from trichoderma viride |
| MFCD00151517 |
| ALAMETHICINRESEARCH GRADE |